2fy5: Difference between revisions

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[[Image:2fy5.jpg|left|200px]]~~<br /><applet load~~="2fy5~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2fy5.jpg|left|200px]]

~~caption="~~2fy5, resolution 2.60Å" />

'''Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis'''~~<br />~~

{{Structure

|PDB= 2fy5 |SIZE=350|CAPTION= <scene name='initialview01'>2fy5</scene>, resolution 2.60Å

|SITE=

|LIGAND= <scene name='pdbligand=SOP:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE'>SOP</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6]

|GENE= CHAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis'''

==Overview==

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==About this Structure==

2FY5 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] ~~with <scene name='pdbligand=SOP:'>SOP</scene> as [http://en.wikipedia~~.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY5 OCA].

2FY5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY5 OCA].

==Reference==

Substrate binding and catalytic mechanism of human choline acetyltransferase., Kim AR, Rylett RJ, Shilton BH, Biochemistry. 2006 Dec 12;45(49):14621-31. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~17144655 17144655]

Substrate binding and catalytic mechanism of human choline acetyltransferase., Kim AR, Rylett RJ, Shilton BH, Biochemistry. 2006 Dec 12;45(49):14621-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17144655 17144655]

[[Category: Choline O-acetyltransferase]]

[[Category: Homo sapiens]]

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[[Category: SOP]]

[[Category: alpha-beta protein]]

[[Category: s-2-(oxopropyl)-coenzyme a]]

[[Category: s-2-(oxopropyl)-coenzyme some]]

[[Category: transferase]]

[[Category: two domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 17~~:26:15 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:58:07 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2fy5.jpg|left|200px]]<br /><applet load="2fy5" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2fy5.jpg|left|200px]]
-caption="2fy5, resolution 2.60&Aring;" />
-'''Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis'''<br />
+ {{Structure
+|PDB= 2fy5 |SIZE=350|CAPTION= <scene name='initialview01'>2fy5</scene>, resolution 2.60&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SOP:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE'>SOP</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6]
+|GENE= CHAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-FY5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SOP:'>SOP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY5 OCA].
+FY5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY5 OCA].
 ==Reference==
-Substrate binding and catalytic mechanism of human choline acetyltransferase., Kim AR, Rylett RJ, Shilton BH, Biochemistry. 2006 Dec 12;45(49):14621-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17144655 17144655]
+Substrate binding and catalytic mechanism of human choline acetyltransferase., Kim AR, Rylett RJ, Shilton BH, Biochemistry. 2006 Dec 12;45(49):14621-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17144655 17144655]
 [[Category: Choline O-acetyltransferase]]
 [[Category: Homo sapiens]]
@@ Line 22: / Line 31: @@
 [[Category: SOP]]
 [[Category: alpha-beta protein]]
-[[Category: s-2-(oxopropyl)-coenzyme a]]
+[[Category: s-2-(oxopropyl)-coenzyme some]]
 [[Category: transferase]]
 [[Category: two domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:58:07 2008''