2fzc: Difference between revisions

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[[Image:2fzc.gif|left|200px]]<br /><applet load="2fzc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fzc.gif|left|200px]]
caption="2fzc, resolution 2.10&Aring;" />
 
'''The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.10 Resolution'''<br />
{{Structure
|PDB= 2fzc |SIZE=350|CAPTION= <scene name='initialview01'>2fzc</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=EOP:{ETHANE-1,2-DIYLBIS[IMINO(2-OXOETHANE-2,1-DIYL)]}BIS(PHOSPHONIC+ACID)'>EOP</scene> and <scene name='pdbligand=CTP:CYTIDINE-5'-TRIPHOSPHATE'>CTP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aspartate_carbamoyltransferase Aspartate carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.2 2.1.3.2]
|GENE= pyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), pyrI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.10 Resolution'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FZC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=EOP:'>EOP</scene> and <scene name='pdbligand=CTP:'>CTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aspartate_carbamoyltransferase Aspartate carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.2 2.1.3.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZC OCA].  
2FZC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZC OCA].  


==Reference==
==Reference==
T-state inhibitors of E. coli aspartate transcarbamoylase that prevent the allosteric transition., Heng S, Stieglitz KA, Eldo J, Xia J, Cardia JP, Kantrowitz ER, Biochemistry. 2006 Aug 22;45(33):10062-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16906764 16906764]
T-state inhibitors of E. coli aspartate transcarbamoylase that prevent the allosteric transition., Heng S, Stieglitz KA, Eldo J, Xia J, Cardia JP, Kantrowitz ER, Biochemistry. 2006 Aug 22;45(33):10062-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16906764 16906764]
[[Category: Aspartate carbamoyltransferase]]
[[Category: Aspartate carbamoyltransferase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: ZN]]
[[Category: ZN]]
[[Category: allosteric transition]]
[[Category: allosteric transition]]
[[Category: inhibitors]]
[[Category: inhibitor]]
[[Category: xray structures]]
[[Category: xray structure]]


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