2fzj: Difference between revisions

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[[Image:2fzj.jpg|left|200px]]<br /><applet load="2fzj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fzj.jpg|left|200px]]
caption="2fzj, resolution 2.0&Aring;" />
 
'''New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives'''<br />
{{Structure
|PDB= 2fzj |SIZE=350|CAPTION= <scene name='initialview01'>2fzj</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=DH3:2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE'>DH3</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE= Dhfr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FZJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=DH3:'>DH3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZJ OCA].  
2FZJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZJ OCA].  


==Reference==
==Reference==
New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions., Cody V, Pace J, Chisum K, Rosowsky A, Proteins. 2006 Dec 1;65(4):959-69. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17019704 17019704]
New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions., Cody V, Pace J, Chisum K, Rosowsky A, Proteins. 2006 Dec 1;65(4):959-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17019704 17019704]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: NAP]]
[[Category: NAP]]
[[Category: dihydrofolate reductase]]
[[Category: dihydrofolate reductase]]
[[Category: ring stacking interactions]]
[[Category: ring stacking interaction]]
[[Category: trimethoprim derivatives]]
[[Category: trimethoprim derivative]]


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