Sandbox Reserved 962: Difference between revisions
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<scene name='60/604481/Interaction_gtg/2'>6 amino acids</scene> (Tyr 145, Leu216, Leu217, Asp218, Ser219, Tyr284) are involded in the binding of the cap analog. {{clear}} | <scene name='60/604481/Interaction_gtg/2'>6 amino acids</scene> (Tyr 145, Leu216, Leu217, Asp218, Ser219, Tyr284) are involded in the binding of the cap analog. {{clear}} | ||
The cap makes Van der Walls contacts with side chains from <scene name='60/604481/Vdw_gtg/1'>Leu216, Leu217, Asp218, Ser219.</scene> {{clear}} | The cap makes Van der Walls contacts with side chains from <scene name='60/604481/Vdw_gtg/1'>Leu216, Leu217, Asp218, Ser219.</scene> {{clear}} | ||
Tyr284 makes a hydrogen bond and Tyr145 a water mediated bond. | <scene name='60/604481/Hb_gtg/1'>Tyr284</scene> makes a hydrogen bond and <scene name='60/604481/Water_gtg/1'>Tyr145</scene> a water mediated bond. | ||
<ref name="Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell. 2004 Jan 16;13(1):77-89. ">PMID:14731396</ref> | <ref name="Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell. 2004 Jan 16;13(1):77-89. ">PMID:14731396</ref> | ||
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<scene name='60/604481/Interaction_sah/1'>10 amino acids</scene> (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. | <scene name='60/604481/Interaction_sah/1'>10 amino acids</scene> (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. | ||
The interactions between AdoHcys and the enzyme are made of : {{clear}} | The interactions between AdoHcys and the enzyme are made of : {{clear}} | ||
- Hydrogen bonds mediated by | - Hydrogen bonds mediated by | ||
- Van der Walls interactions mediated by | <scene name='60/604481/Hd_sah/1'>Lys54, Gly72, Asp94, Asp122, Gln140</scene> {{clear}} | ||
- An electrostatic interaction mediated by Gln140 | - Van der Walls interactions mediated by | ||
- A water mediated contact mediated by Asp78 | <scene name='60/604481/Vdw_sah/1'>Ile95, Tyr124 and Ser142</scene> {{clear}} | ||
- An electrostatic interaction mediated by <scene name='60/604481/Elec_sah/1'>Gln140 and Phe141</scene> {{clear}} | |||
- A water mediated contact mediated by <scene name='60/604481/Water_sah/1'>Asp78</scene> | |||
<ref name="Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell. 2004 Jan 16;13(1):77-89. ">PMID:14731396</ref> | <ref name="Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell. 2004 Jan 16;13(1):77-89. ">PMID:14731396</ref> | ||
