2g0h: Difference between revisions

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[[Image:2g0h.gif|left|200px]]<br /><applet load="2g0h" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2g0h.gif|left|200px]]
caption="2g0h, resolution 2.3&Aring;" />
 
'''Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities'''<br />
{{Structure
|PDB= 2g0h |SIZE=350|CAPTION= <scene name='initialview01'>2g0h</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SP3:N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]-3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE'>SP3</scene>
|ACTIVITY=
|GENE= PPARG, NR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2G0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SP3:'>SP3</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0H OCA].  
2G0H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0H OCA].  


==Reference==
==Reference==
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities., Lu IL, Huang CF, Peng YH, Lin YT, Hsieh HP, Chen CT, Lien TW, Lee HJ, Mahindroo N, Prakash E, Yueh A, Chen HY, Goparaju CM, Chen X, Liao CC, Chao YS, Hsu JT, Wu SY, J Med Chem. 2006 May 4;49(9):2703-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16640330 16640330]
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities., Lu IL, Huang CF, Peng YH, Lin YT, Hsieh HP, Chen CT, Lien TW, Lee HJ, Mahindroo N, Prakash E, Yueh A, Chen HY, Goparaju CM, Chen X, Liao CC, Chao YS, Hsu JT, Wu SY, J Med Chem. 2006 May 4;49(9):2703-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16640330 16640330]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ppar]]
[[Category: ppar]]


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