Sandbox Reserved 975: Difference between revisions
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== Function == | == Function == | ||
The active site residue <scene name='60/604494/Cys_93/1'>Cys 93</scene> is located in a <scene name='60/604494/Crevice_formes_by_2_loops/1'>crevice</scene>formed by a loop between β4 and α2 (85-102) and another one between α2 and α3 (residues 122-130) | The active site residue <scene name='60/604494/Cys_93/1'>Cys 93</scene> is located in a <scene name='60/604494/Crevice_formes_by_2_loops/1'>crevice</scene> formed by a loop between β4 and α2 (85-102) and another one between α2 and α3 (residues 122-130). | ||
<scene name='60/604494/Five_residues_of_the_sa/1'>Five residues</scene> are the most likely to participate to the catalytic action because they are located within 6 Å of the sulfhydryl group of the accepting cysteine and that their side chains are oriented toward the Cysteine : Asn85, Tyr87, Glu98, Lys101, and Asp127. | |||
15 residues are well conserved among the UBC family : Gly47, Lys48, Gly56, Tyr68, Pro69, Pro73, Phe77, His83, Pro84, Asn85, Gly90, Trp103, Pro105, Leu120, and Pro12 | 15 residues are well conserved among the UBC family : Gly47, Lys48, Gly56, Tyr68, Pro69, Pro73, Phe77, His83, Pro84, Asn85, Gly90, Trp103, Pro105, Leu120, and Pro12 | ||
