Sandbox Reserved 963: Difference between revisions
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Besides, we observe no contact between Aβ and the L2 or H1 CDRs of WO2 and there is no evidence in the structure of any water-mediated contacts between WO2 and Aβ.<ref>Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.,Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW J Mol Biol. 2008 Mar 14;377(1):181-92. Epub 2008 Jan 30. PMID:18237744</ref> | Besides, we observe no contact between Aβ and the L2 or H1 CDRs of WO2 and there is no evidence in the structure of any water-mediated contacts between WO2 and Aβ.<ref>Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.,Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW J Mol Biol. 2008 Mar 14;377(1):181-92. Epub 2008 Jan 30. PMID:18237744</ref> | ||
===Details of the close interactions between WO2 and Aβ(2-8)=== | ===Details of the close interactions between WO2 and Aβ(2-8)=== | ||
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====The special case of Asp7==== | ====The special case of Asp7==== | ||
Asp7 sits above a large water-filled cavity in the Fab antigen binding site but makes no direct or water-mediated contacts with WO2. | Asp7 sits above a large water-filled cavity in the Fab antigen binding site but makes no direct or water-mediated contacts with WO2. | ||
===Comparison of unliganted and liganted WO2 Fab structures=== | ===Comparison of unliganted and liganted WO2 Fab structures=== | ||
