Sandbox Reserved 963: Difference between revisions
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The structure of WO2 that is described here is that of WO2 murine anti-Aβ monoclonal Fab in the space group P2<sub>1</sub>2<sub>1</sub>2<sub>1</sub> (Form A) (the Form B, not discussed here, corresponds to the WO2 Fab crystallized in the space group P2<sub>1</sub>). Thus, in what follows, the different features correspond to the Form A. | The structure of WO2 that is described here is that of WO2 murine anti-Aβ monoclonal Fab in the space group P2<sub>1</sub>2<sub>1</sub>2<sub>1</sub> (Form A) (the Form B, not discussed here, corresponds to the WO2 Fab crystallized in the space group P2<sub>1</sub>). Thus, in what follows, the different features correspond to the Form A. | ||
This structure appears to be that of a typical immunoglobulin (Ig) Fab heavy-chain/light-chain heterodimer | This structure appears to be that of a typical immunoglobulin (Ig) Fab heavy-chain/light-chain heterodimer '''(Figure 1)'''. The heavy chain is made up of 252 amino acids while the light chain is made up of 224 amino acids.<ref>http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=63842</ref> [[Image:Fig. 1a.png|thumb|'''Figure 1 :''' WO2 Fab variable domain structures after superimposition of their Cα atoms. Form A is in yellow and Form B is in green<ref>Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.,Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW J Mol Biol. 2008 Mar 14;377(1):181-92. Epub 2008 Jan 30. PMID:18237744</ref>]] | ||
In Form A, we notice an elbow angle of 192°. | In Form A, we notice an elbow angle of 192°. | ||
