2g6p: Difference between revisions

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[[Image:2g6p.gif|left|200px]]<br /><applet load="2g6p" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2g6p.gif|left|200px]]
caption="2g6p, resolution 1.90&Aring;" />
 
'''Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative'''<br />
{{Structure
|PDB= 2g6p |SIZE=350|CAPTION= <scene name='initialview01'>2g6p</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=HM2:5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE'>HM2</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18]
|GENE= METAP1, KIAA0094 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative'''
 


==About this Structure==
==About this Structure==
2G6P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CO:'>CO</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=HM2:'>HM2</scene>, <scene name='pdbligand=EPE:'>EPE</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6P OCA].  
2G6P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6P OCA].  


==Reference==
==Reference==
Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases., Hu X, Addlagatta A, Matthews BW, Liu JO, Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3772-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16724298 16724298]
Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases., Hu X, Addlagatta A, Matthews BW, Liu JO, Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3772-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16724298 16724298]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Methionyl aminopeptidase]]
[[Category: Methionyl aminopeptidase]]
Line 24: Line 33:
[[Category: pyridinyl pyrimidine]]
[[Category: pyridinyl pyrimidine]]


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