2g8e: Difference between revisions

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[[Image:2g8e.gif|left|200px]]<br /><applet load="2g8e" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2g8e.gif|left|200px]]
caption="2g8e, resolution 2.25&Aring;" />
 
'''Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor'''<br />
{{Structure
|PDB= 2g8e |SIZE=350|CAPTION= <scene name='initialview01'>2g8e</scene>, resolution 2.25&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D5G:(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE'>D5G</scene> and <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID'>MES</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52]
|GENE= Capn1, Cls1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2G8E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=D5G:'>D5G</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8E OCA].  
2G8E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8E OCA].  


==Reference==
==Reference==
Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography., Cuerrier D, Moldoveanu T, Inoue J, Davies PL, Campbell RL, Biochemistry. 2006 Jun 20;45(24):7446-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16768440 16768440]
Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography., Cuerrier D, Moldoveanu T, Inoue J, Davies PL, Campbell RL, Biochemistry. 2006 Jun 20;45(24):7446-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16768440 16768440]
[[Category: Calpain-1]]
[[Category: Calpain-1]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: protease]]
[[Category: protease]]


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