3tc2: Difference between revisions

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{{STRUCTURE_3tc2|  PDB=3tc2 | SCENE= }}
==Crystal structure of potato serine protease inhibitor.==
===Crystal structure of potato serine protease inhibitor.===
<StructureSection load='3tc2' size='340' side='right' caption='[[3tc2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
{{ABSTRACT_PUBMED_22751664}}
== Structural highlights ==
<table><tr><td colspan='2'>[[3tc2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TC2 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tc2 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc2 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Potato serine protease inhibitor (PSPI) constitutes about 22% of the total amount of proteins in potato tubers (cv. Elkana), making it the most abundant protease inhibitor in the plant. PSPI is a heterodimeric double-headed Kunitz-type serine protease inhibitor that can tightly and simultaneously bind two serine proteases by mimicking the substrate of the enzyme with its reactive-site loops. Here, the crystal structure of PSPI is reported, representing the first heterodimeric double-headed Kunitz-type serine protease inhibitor structure to be determined. PSPI has a beta-trefoil fold and, based on the structure, two reactive-site loops bearing residues Phe75 and Lys95 were identified.


==About this Structure==
Structure of a post-translationally processed heterodimeric double-headed Kunitz-type serine protease inhibitor from potato.,Meulenbroek EM, Thomassen EA, Pouvreau L, Abrahams JP, Gruppen H, Pannu NS Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):794-9. doi:, 10.1107/S090744491201222X. Epub 2012 Jun 15. PMID:22751664<ref>PMID:22751664</ref>
[[3tc2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC2 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:022751664</ref><references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Solanum tuberosum]]
[[Category: Solanum tuberosum]]
[[Category: Meulenbroek, E M.]]
[[Category: Meulenbroek, E M]]
[[Category: Pannu, N S.]]
[[Category: Pannu, N S]]
[[Category: Thomassen, E A.J.]]
[[Category: Thomassen, E A.J]]
[[Category: Beta-trefoil fold]]
[[Category: Beta-trefoil fold]]
[[Category: Hydrolase inhibitor]]
[[Category: Hydrolase inhibitor]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
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