2gnh: Difference between revisions

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[[Image:2gnh.gif|left|200px]]<br /><applet load="2gnh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2gnh.gif|left|200px]]
caption="2gnh, resolution 2.05&Aring;" />
 
'''PKA five fold mutant model of Rho-kinase with H1152P'''<br />
{{Structure
|PDB= 2gnh |SIZE=350|CAPTION= <scene name='initialview01'>2gnh</scene>, resolution 2.05&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=H52:(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE'>H52</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11]
|GENE= PRKACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
}}
 
'''PKA five fold mutant model of Rho-kinase with H1152P'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2GNH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=H52:'>H52</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNH OCA].  
2GNH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNH OCA].  


==Reference==
==Reference==
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity., Bonn S, Herrero S, Breitenlechner CB, Erlbruch A, Lehmann W, Engh RA, Gassel M, Bossemeyer D, J Biol Chem. 2006 Aug 25;281(34):24818-30. Epub 2006 May 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16699172 16699172]
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity., Bonn S, Herrero S, Breitenlechner CB, Erlbruch A, Lehmann W, Engh RA, Gassel M, Bossemeyer D, J Biol Chem. 2006 Aug 25;281(34):24818-30. Epub 2006 May 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16699172 16699172]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: surrogate]]
[[Category: surrogate]]


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