2gtk: Difference between revisions

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[[Image:2gtk.gif|left|200px]]<br /><applet load="2gtk" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2gtk.gif|left|200px]]
caption="2gtk, resolution 2.10&Aring;" />
 
'''Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists'''<br />
{{Structure
|PDB= 2gtk |SIZE=350|CAPTION= <scene name='initialview01'>2gtk</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=208:(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID'>208</scene>
|ACTIVITY=
|GENE= PPARG, NR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2GTK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=208:'>208</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTK OCA].  
2GTK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTK OCA].  


==Reference==
==Reference==
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists., Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Marki HP, Meyer M, Mohr P, Bioorg Med Chem Lett. 2006 Aug 1;16(15):4016-20. Epub 2006 Jun 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16737814 16737814]
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists., Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Marki HP, Meyer M, Mohr P, Bioorg Med Chem Lett. 2006 Aug 1;16(15):4016-20. Epub 2006 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16737814 16737814]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: nuclear receptor]]
[[Category: nuclear receptor]]


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