2gwc: Difference between revisions

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[[Image:2gwc.gif|left|200px]]<br /><applet load="2gwc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2gwc.gif|left|200px]]
caption="2gwc, resolution 2.18&Aring;" />
 
'''Crystal structure of plant glutamate cysteine ligase in complex with a transition state analogue'''<br />
{{Structure
|PDB= 2gwc |SIZE=350|CAPTION= <scene name='initialview01'>2gwc</scene>, resolution 2.18&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=BSC:(S)-2-AMINO-4-(AMINO-BUTYLHYDROSULFINYL)BUTANOIC ACID'>BSC</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutamate--cysteine_ligase Glutamate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.2 6.3.2.2]
|GENE= GSH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3707 Brassica juncea])
}}
 
'''Crystal structure of plant glutamate cysteine ligase in complex with a transition state analogue'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2GWC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=BSC:'>BSC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutamate--cysteine_ligase Glutamate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.2 6.3.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWC OCA].  
2GWC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWC OCA].  


==Reference==
==Reference==
Structural basis for the redox control of plant glutamate cysteine ligase., Hothorn M, Wachter A, Gromes R, Stuwe T, Rausch T, Scheffzek K, J Biol Chem. 2006 Sep 15;281(37):27557-65. Epub 2006 Jun 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16766527 16766527]
Structural basis for the redox control of plant glutamate cysteine ligase., Hothorn M, Wachter A, Gromes R, Stuwe T, Rausch T, Scheffzek K, J Biol Chem. 2006 Sep 15;281(37):27557-65. Epub 2006 Jun 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16766527 16766527]
[[Category: Brassica juncea]]
[[Category: Brassica juncea]]
[[Category: Glutamate--cysteine ligase]]
[[Category: Glutamate--cysteine ligase]]
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[[Category: MG]]
[[Category: MG]]
[[Category: beta-hairpin]]
[[Category: beta-hairpin]]
[[Category: disulfide bridges]]
[[Category: disulfide bridge]]
[[Category: glutathione biosynthesis]]
[[Category: glutathione biosynthesis]]
[[Category: redox regulation]]
[[Category: redox regulation]]


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