4fes: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of OSH4 in complex with cholesterol analogs== | |||
=== | <StructureSection load='4fes' size='340' side='right' caption='[[4fes]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FES FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T9:(3S,8S,9S,10R,13S,14S,17R)-3-HYDROXY-10,13-DIMETHYL-17-[(2S,6S)-6-METHYL-3-OXOOCTAN-2-YL]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-TETRADECAHYDRO-16H-CYCLOPENTA[A]PHENANTHREN-16-ONE'>0T9</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zhy|1zhy]], [[4f4b|4f4b]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KES1, OSH4, YPL145C, LPI3C, P2614 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fes RCSB], [http://www.ebi.ac.uk/pdbsum/4fes PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations. | |||
Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172<ref>PMID:23756172</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Saccharomyces cerevisiae s288c]] | [[Category: Saccharomyces cerevisiae s288c]] | ||
[[Category: Cheun, Y | [[Category: Cheun, Y]] | ||
[[Category: Koag, M C | [[Category: Koag, M C]] | ||
[[Category: Lee, S | [[Category: Lee, S]] | ||
[[Category: Monzingo, A F | [[Category: Monzingo, A F]] | ||
[[Category: Lipid binding protein]] | [[Category: Lipid binding protein]] | ||
[[Category: Oxysterol]] | [[Category: Oxysterol]] | ||
[[Category: Sterol binding protein]] | [[Category: Sterol binding protein]] | ||
Revision as of 12:35, 4 January 2015
Structure of OSH4 in complex with cholesterol analogs
| ||||||||||||
