4izg: Difference between revisions
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==Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)== | |||
<StructureSection load='4izg' size='340' side='right' caption='[[4izg]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4izg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans_pd1222 Paracoccus denitrificans pd1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OP:(2S,4S)-2-CARBOXY-4-HYDROXY-1,1-DIMETHYLPYRROLIDINIUM'>4OP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4izg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4izg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4izg RCSB], [http://www.ebi.ac.uk/pdbsum/4izg PDBsum]</span></td></tr> | |||
</table> | |||
== | == Function == | ||
[[4izg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans_pd1222 Paracoccus denitrificans pd1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZG OCA]. | [[http://www.uniprot.org/uniprot/A1B198_PARDP A1B198_PARDP]] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Paracoccus denitrificans pd1222]] | [[Category: Paracoccus denitrificans pd1222]] | ||
[[Category: Almo, S C | [[Category: Almo, S C]] | ||
[[Category: Bhosle, R | [[Category: Bhosle, R]] | ||
[[Category: Bonanno, J B | [[Category: Bonanno, J B]] | ||
[[Category: Chamala, S | [[Category: Chamala, S]] | ||
[[Category: Evans, B | [[Category: Evans, B]] | ||
[[Category: Gerlt, J A | [[Category: Gerlt, J A]] | ||
[[Category: Gizzi, A | [[Category: Gizzi, A]] | ||
[[Category: Hammonds, J | [[Category: Hammonds, J]] | ||
[[Category: Hillerich, B | [[Category: Hillerich, B]] | ||
[[Category: Kar, A | [[Category: Kar, A]] | ||
[[Category: LaFleur, J | [[Category: LaFleur, J]] | ||
[[Category: Love, J | [[Category: Love, J]] | ||
[[Category: Morisco, L L | [[Category: Morisco, L L]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Seidel, R D | [[Category: Seidel, R D]] | ||
[[Category: Sojitra, S | [[Category: Sojitra, S]] | ||
[[Category: Stead, M | [[Category: Stead, M]] | ||
[[Category: Toro, R | [[Category: Toro, R]] | ||
[[Category: Vetting, M W | [[Category: Vetting, M W]] | ||
[[Category: Villigas, G | [[Category: Villigas, G]] | ||
[[Category: Wasserman, S R | [[Category: Wasserman, S R]] | ||
[[Category: Betaine racemase]] | [[Category: Betaine racemase]] | ||
[[Category: Enolase]] | [[Category: Enolase]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Nysgrc]] | [[Category: Nysgrc]] | ||
[[Category: Proline betaine racemease]] | [[Category: Proline betaine racemease]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
