4c5x: Difference between revisions

Line 1:

~~{{STRUCTURE_4c5x| PDB=4c5x | SCENE= }}~~

==Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification==

===Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification===

~~{{ABSTRACT_PUBMED_24287551}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4c5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C5X FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c63|4c63]], [[4c64|4c64]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c5x RCSB], [http://www.ebi.ac.uk/pdbsum/4c5x PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Transcription factor binding and high resolution crystallographic studies (1.3 A) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

~~==About this Structure==~~

Structural insights into how 5-hydroxymethylation influences transcription factor binding.,Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ Chem Commun (Camb). 2013 Nov 29. PMID:24287551<ref>PMID:24287551</ref>

~~[[4c5x]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4C5X OCA].~~

==~~Reference~~==

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:024287551</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

[[Category: Brown, T.]]

== References ==

[[Category: El-Sagheer, A H.]]

[[Category: McDonough, M.]]

__TOC__

[[Category: Schofield, C J.]]

</StructureSection>

[[Category: Brown, T]]

[[Category: El-Sagheer, A H]]

[[Category: McDonough, M]]

[[Category: Schofield, C J]]

[[Category: Cytosine modification]]

[[Category: Dna]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4c5x|  PDB=4c5x  |  SCENE=  }}
+==Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification==
-===Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification===
+<StructureSection load='4c5x' size='340' side='right' caption='[[4c5x]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-{{ABSTRACT_PUBMED_24287551}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4c5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C5X FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c63|4c63]], [[4c64|4c64]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c5x RCSB], [http://www.ebi.ac.uk/pdbsum/4c5x PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Transcription factor binding and high resolution crystallographic studies (1.3 A) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.
-==About this Structure==
+Structural insights into how 5-hydroxymethylation influences transcription factor binding.,Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ Chem Commun (Camb). 2013 Nov 29. PMID:24287551<ref>PMID:24287551</ref>
-[[4c5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5X OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024287551</ref><references group="xtra"/><references/>
+</div>
-[[Category: Brown, T.]]
+== References ==
-[[Category: El-Sagheer, A H.]]
+<references/>
-[[Category: McDonough, M.]]
+__TOC__
-[[Category: Schofield, C J.]]
+</StructureSection>
+[[Category: Brown, T]]
+[[Category: El-Sagheer, A H]]
+[[Category: McDonough, M]]
+[[Category: Schofield, C J]]
 [[Category: Cytosine modification]]
 [[Category: Dna]]