4iye: Difference between revisions
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==Crystal structure of AdTx1 (rho-Da1a) from eastern green mamba (Dendroaspis angusticeps)== | |||
=== | <StructureSection load='4iye' size='340' side='right' caption='[[4iye]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4iye]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vlw|2vlw]], [[3fev|3fev]], [[3neq|3neq]], [[4do8|4do8]], [[1ff4|1ff4]], [[2h5f|2h5f]], [[2h7z|2h7z]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iye RCSB], [http://www.ebi.ac.uk/pdbsum/4iye PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
rho-Da1a toxin from eastern green mamba (Dendroaspis angusticeps) venom is a polypeptide of 65 amino acids with a strong affinity for the G-protein-coupled alpha(1A)-adrenoceptor. This neurotoxin has been crystallized from resolubilized lyophilized powder, but the best crystals grew spontaneously during lyophilization. The crystals belonged to the trigonal space group P3(1)21, with unit-cell parameters a = b = 37.37, c = 66.05 A, and diffracted to 1.95 A resolution. The structure solved by molecular replacement showed strong similarities to green mamba muscarinic toxins. | |||
Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination.,Maiga A, Vera L, Marchetti C, Lorphelin A, Bellanger L, Mourier G, Servent D, Gilles N, Stura EA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):704-9. doi:, 10.1107/S1744309113011470. Epub 2013 May 29. PMID:23722859<ref>PMID:23722859</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dendroaspis angusticeps]] | [[Category: Dendroaspis angusticeps]] | ||
[[Category: Bellanger, L | [[Category: Bellanger, L]] | ||
[[Category: Gilles, N | [[Category: Gilles, N]] | ||
[[Category: Lorphelin, A | [[Category: Lorphelin, A]] | ||
[[Category: Maiga, A A | [[Category: Maiga, A A]] | ||
[[Category: Marchetti, C | [[Category: Marchetti, C]] | ||
[[Category: Servant, D | [[Category: Servant, D]] | ||
[[Category: Stura, E A | [[Category: Stura, E A]] | ||
[[Category: Vera, L | [[Category: Vera, L]] | ||
[[Category: Acts as a relaxant of smooth muscle]] | [[Category: Acts as a relaxant of smooth muscle]] | ||
[[Category: Alpha-1a adrenergic receptor]] | [[Category: Alpha-1a adrenergic receptor]] | ||
Revision as of 13:16, 4 January 2015
Crystal structure of AdTx1 (rho-Da1a) from eastern green mamba (Dendroaspis angusticeps)
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