2h4n: Difference between revisions

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[[Image:2h4n.jpg|left|200px]]~~<br /><applet load~~="2h4n~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2h4n.jpg|left|200px]]

~~caption="~~2h4n, resolution 1.9Å" />

'''H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE'''~~<br />~~

{{Structure

|PDB= 2h4n |SIZE=350|CAPTION= <scene name='initialview01'>2h4n</scene>, resolution 1.9Å

|SITE= <scene name='pdbsite=ZN:Active+Site,+Zn+Binding+Site'>ZN</scene>

|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]

|GENE= CAII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE'''

==Overview==

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==About this Structure==

2H4N is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=AZM:'>AZM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Known structural/functional Site: <scene name='pdbsite=ZN:Active+Site,+Zn+Binding+Site'>ZN</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4N OCA].

2H4N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4N OCA].

==Reference==

Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity., Lesburg CA, Huang C, Christianson DW, Fierke CA, Biochemistry. 1997 Dec 16;36(50):15780-91. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~9398308 9398308]

Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity., Lesburg CA, Huang C, Christianson DW, Fierke CA, Biochemistry. 1997 Dec 16;36(50):15780-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9398308 9398308]

[[Category: Carbonate dehydratase]]

[[Category: Homo sapiens]]

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[[Category: oxo-acid]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21~~ 17:38:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:12:43 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2h4n.jpg|left|200px]]<br /><applet load="2h4n" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2h4n.jpg|left|200px]]
-caption="2h4n, resolution 1.9&Aring;" />
-'''H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE'''<br />
+ {{Structure
+|PDB= 2h4n |SIZE=350|CAPTION= <scene name='initialview01'>2h4n</scene>, resolution 1.9&Aring;
+|SITE= <scene name='pdbsite=ZN:Active+Site,+Zn+Binding+Site'>ZN</scene>
+|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]
+|GENE= CAII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-H4N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=AZM:'>AZM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Known structural/functional Site: <scene name='pdbsite=ZN:Active+Site,+Zn+Binding+Site'>ZN</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4N OCA].
+H4N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4N OCA].
 ==Reference==
-Histidine --&gt; carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity., Lesburg CA, Huang C, Christianson DW, Fierke CA, Biochemistry. 1997 Dec 16;36(50):15780-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9398308 9398308]
+Histidine --&gt; carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity., Lesburg CA, Huang C, Christianson DW, Fierke CA, Biochemistry. 1997 Dec 16;36(50):15780-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9398308 9398308]
 [[Category: Carbonate dehydratase]]
 [[Category: Homo sapiens]]
@@ Line 25: / Line 34: @@
 [[Category: oxo-acid]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:38:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:12:43 2008''