2h5l: Difference between revisions

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[[Image:2h5l.jpg|left|200px]]<br /><applet load="2h5l" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2h5l.jpg|left|200px]]
caption="2h5l, resolution 2.8&Aring;" />
 
'''S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine'''<br />
{{Structure
|PDB= 2h5l |SIZE=350|CAPTION= <scene name='initialview01'>2h5l</scene>, resolution 2.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=3DD:(2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID'>3DD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1]
|GENE= Ahcy ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2H5L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=3DD:'>3DD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5L OCA].  
2H5L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5L OCA].  


==Reference==
==Reference==
Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents., Yamada T, Komoto J, Lou K, Ueki A, Hua DH, Sugiyama K, Takata Y, Ogawa H, Takusagawa F, Biochem Pharmacol. 2007 Apr 1;73(7):981-9. Epub 2006 Dec 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17214973 17214973]
Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents., Yamada T, Komoto J, Lou K, Ueki A, Hua DH, Sugiyama K, Takata Y, Ogawa H, Takusagawa F, Biochem Pharmacol. 2007 Apr 1;73(7):981-9. Epub 2006 Dec 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17214973 17214973]
[[Category: Adenosylhomocysteinase]]
[[Category: Adenosylhomocysteinase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: s-adenosylhomocysteine]]
[[Category: s-adenosylhomocysteine]]


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