4hvz: Difference between revisions
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==Crystal structure of brucella abortus immunogenic BP26 protein== | |||
=== | <StructureSection load='4hvz' size='340' side='right' caption='[[4hvz]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hvz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus_s19 Brucella abortus s19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HVZ FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bp26, BAbS19_I13950 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=430066 Brucella abortus S19])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hvz RCSB], [http://www.ebi.ac.uk/pdbsum/4hvz PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
An outer membrane protein BP26/OMP28 of Brucella, BP26, is identified as a major immunodominant antigen and widely used as a diagnostic marker and for vaccination against Brucellosis. BP26 belongs to the family of proteins that contains a SIMPL (signaling molecule that associates with the mouse pelle-like kinase) domain, whose structure and function have been unknown. Here, we present the crystal structure of BP26 revealing that 16 BP26 molecules form a novel channel-like assembly as also shown by electron microscopy analysis. Eight BP26 molecules forming a ring structure contain a hole at the center of the octamer, and another octamer interacts with each other to form a channel having a large internal cavity. BP26 is found to be structurally similar to a bacteriophage protein involved in infection, implicating that BP26 might function during Brucella infection. In addition, the BP26 structure suggests that the protein functions as a multimeric channel-like form and provides a canonical model for the SIMPL domains. | |||
Brucella Immunogenic BP26 Forms a Channel-like Structure.,Kim D, Park J, Kim SJ, Soh YM, Kim HM, Oh BH, Song JJ J Mol Biol. 2013 Jan 23. pii: S0022-2836(13)00031-4. doi:, 10.1016/j.jmb.2013.01.015. PMID:23353825<ref>PMID:23353825</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brucella abortus s19]] | [[Category: Brucella abortus s19]] | ||
[[Category: Kim, D | [[Category: Kim, D]] | ||
[[Category: Oh, B | [[Category: Oh, B]] | ||
[[Category: Park, J | [[Category: Park, J]] | ||
[[Category: Song, J | [[Category: Song, J]] | ||
[[Category: Infection]] | [[Category: Infection]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Multimerization]] | [[Category: Multimerization]] | ||
[[Category: Simpl domain]] | [[Category: Simpl domain]] | ||
