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[[Image:4fr0.png|left|200px]]
==ArsM arsenic(III) S-adenosylmethionine methyltransferase with SAM==
<StructureSection load='4fr0' size='340' side='right' caption='[[4fr0]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyanidioschyzon_sp._5508 Cyanidioschyzon sp. 5508]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qhu 3qhu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FR0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fs8|4fs8]], [[4fsd|4fsd]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">arsM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=610260 Cyanidioschyzon sp. 5508])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fr0 RCSB], [http://www.ebi.ac.uk/pdbsum/4fr0 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Enzymatic methylation of arsenic is a detoxification process in microorganisms but in humans may activate the metalloid to more carcinogenic species. We describe the first structure of an As(III) S-adenosylmethionine methyltransferase by X-ray crystallography that reveals a novel As(III) binding domain. The structure of the methyltransferase from the thermophilic eukaryotic alga Cyanidioschyzon merolae reveals the relationship between the arsenic and S-adenosylmethionine binding sites to a final resolution of approximately 1.6 A. As(III) binding causes little change in conformation, but binding of SAM reorients helix alpha4 and a loop (residues 49-80) toward the As(III) binding domain, positioning the methyl group for transfer to the metalloid. There is no evidence of a reductase domain. These results are consistent with previous suggestions that arsenic remains trivalent during the catalytic cycle. A homology model of human As(III) S-adenosylmethionine methyltransferase with the location of known polymorphisms was constructed. The structure provides insights into the mechanism of substrate binding and catalysis.


{{STRUCTURE_4fr0|  PDB=4fr0  |  SCENE=  }}
Structure of an As(III) S-Adenosylmethionine Methyltransferase: Insights into the Mechanism of Arsenic Biotransformation.,Ajees AA, Marapakala K, Packianathan C, Sankaran B, Rosen BP Biochemistry. 2012 Jun 29. PMID:22712827<ref>PMID:22712827</ref>


===ArsM arsenic(III) S-adenosylmethionine methyltransferase with SAM===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22712827}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[4fr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyanidioschyzon_sp._5508 Cyanidioschyzon sp. 5508]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qhu 3qhu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FR0 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:022712827</ref><references group="xtra"/>
[[Category: Cyanidioschyzon sp. 5508]]
[[Category: Cyanidioschyzon sp. 5508]]
[[Category: Ajees, A A.]]
[[Category: Ajees, A A]]
[[Category: Marapakala, K.]]
[[Category: Marapakala, K]]
[[Category: Packianathan, C.]]
[[Category: Packianathan, C]]
[[Category: Rosen, B P.]]
[[Category: Rosen, B P]]
[[Category: Sankaran, B.]]
[[Category: Sankaran, B]]
[[Category: Arsenic methyltransferase]]
[[Category: Arsenic methyltransferase]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
[[Category: Transferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4fr0"