2hb3: Difference between revisions

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[[Image:2hb3.gif|left|200px]]<br /><applet load="2hb3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hb3.gif|left|200px]]
caption="2hb3, resolution 1.35&Aring;" />
 
'''Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579'''<br />
{{Structure
|PDB= 2hb3 |SIZE=350|CAPTION= <scene name='initialview01'>2hb3</scene>, resolution 1.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=GRL:(3AS,5R,6AR)-HEXAHYDRO-2H-CYCLOPENTA[B]FURAN-5-YL+(2S,3S)-3-HYDROXY-4-(4-(HYDROXYMETHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE'>GRL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Chymosin Chymosin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.4 3.4.23.4]
|GENE= GAG, POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HB3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=GRL:'>GRL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Chymosin Chymosin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.4 3.4.23.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB3 OCA].  
2HB3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB3 OCA].  


==Reference==
==Reference==
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance., Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H, J Med Chem. 2006 Aug 24;49(17):5252-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16913714 16913714]
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance., Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H, J Med Chem. 2006 Aug 24;49(17):5252-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16913714 16913714]
[[Category: Chymosin]]
[[Category: Chymosin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: active-site cavity protease inhibitor catalytic aspartic acid]]
[[Category: active-site cavity protease inhibitor catalytic aspartic acid]]


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