2hct: Difference between revisions

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[[Image:2hct.gif|left|200px]]<br /><applet load="2hct" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hct.gif|left|200px]]
caption="2hct, resolution 1.95&Aring;" />
 
'''Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities'''<br />
{{Structure
|PDB= 2hct |SIZE=350|CAPTION= <scene name='initialview01'>2hct</scene>, resolution 1.95&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NMN:BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE'>NMN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5]
|GENE= CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NMN:'>NMN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCT OCA].  
2HCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCT OCA].  


==Reference==
==Reference==
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities., Graeff R, Liu Q, Kriksunov IA, Hao Q, Lee HC, J Biol Chem. 2006 Sep 29;281(39):28951-7. Epub 2006 Jul 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16861223 16861223]
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities., Graeff R, Liu Q, Kriksunov IA, Hao Q, Lee HC, J Biol Chem. 2006 Sep 29;281(39):28951-7. Epub 2006 Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16861223 16861223]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: NAD(+) nucleosidase]]
[[Category: NAD(+) nucleosidase]]
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[[Category: NMN]]
[[Category: NMN]]
[[Category: alpha bundle]]
[[Category: alpha bundle]]
[[Category: beta sheets]]
[[Category: beta sheet]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:26 2008''
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