2hds: Difference between revisions

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[[Image:2hds.gif|left|200px]]<br /><applet load="2hds" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hds.gif|left|200px]]
caption="2hds, resolution 1.160&Aring;" />
 
'''AmpC beta-lactamase in complex with 4-Methanesulfonylamino benzoic acid'''<br />
{{Structure
|PDB= 2hds |SIZE=350|CAPTION= <scene name='initialview01'>2hds</scene>, resolution 1.160&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SUC:SUCROSE'>SUC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=4MB:4-[(METHYLSULFONYL)AMINO]BENZOIC ACID'>4MB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= ampC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''AmpC beta-lactamase in complex with 4-Methanesulfonylamino benzoic acid'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HDS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SUC:'>SUC</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=4MB:'>4MB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDS OCA].  
2HDS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDS OCA].  


==Reference==
==Reference==
Deconstructing fragment-based inhibitor discovery., Babaoglu K, Shoichet BK, Nat Chem Biol. 2006 Dec;2(12):720-3. Epub 2006 Oct 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17072304 17072304]
Deconstructing fragment-based inhibitor discovery., Babaoglu K, Shoichet BK, Nat Chem Biol. 2006 Dec;2(12):720-3. Epub 2006 Oct 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17072304 17072304]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: ampc beta-lactamase fragment-based drug design]]
[[Category: ampc beta-lactamase fragment-based drug design]]


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