4map: Difference between revisions
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==Crystal structure of Ara h 8 purified with heating== | |||
<StructureSection load='4map' size='340' side='right' caption='[[4map]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4map]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arahy Arahy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MAP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m9b|4m9b]], [[4m9w|4m9w]], [[4ma6|4ma6]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4map FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4map OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4map RCSB], [http://www.ebi.ac.uk/pdbsum/4map PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The incidence of peanut allergy continues to rise in the United States and Europe. Whereas exposure to the major allergens Ara h 1, 2, 3, and 6 can cause fatal anaphylaxis, exposure to the minor allergens usually does not. Ara h 8 is a minor allergen. Importantly, it is the minor food allergens that are thought to be responsible for oral allergy syndrome (OAS), in which sensitization to airborne allergens causes a Type 2 allergic reaction to ingested foods. Furthermore, it is believed that similar protein structure rather than a similar linear sequence is the cause of OAS. Bet v 1 from birch pollen is a common sensitizing agent, and OAS results when patients consume certain fruits, vegetables, tree nuts, and peanuts. Here, we report the three-dimensional structure of Ara h 8, a Bet v 1 homolog. The overall fold is very similar to that of Bet v 1, Api g 1 (celery), Gly m 4 (soy), and Pru av 1 (cherry). Ara h 8 binds the isoflavones quercetin and apigenin as well as resveratrol avidly. | |||
Structure and Function of the Peanut Panallergen Ara h 8.,Hurlburt BK, Offermann LR, McBride JK, Majorek KA, Maleki SJ, Chruszcz M J Biol Chem. 2013 Dec 27;288(52):36890-901. doi: 10.1074/jbc.M113.517797. Epub, 2013 Nov 19. PMID:24253038<ref>PMID:24253038</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arahy]] | [[Category: Arahy]] | ||
[[Category: Chruszcz, M | [[Category: Chruszcz, M]] | ||
[[Category: Hurlburt, B K | [[Category: Hurlburt, B K]] | ||
[[Category: Majorek, K A | [[Category: Majorek, K A]] | ||
[[Category: Maleki, S J | [[Category: Maleki, S J]] | ||
[[Category: McBride, J K | [[Category: McBride, J K]] | ||
[[Category: Offermann, L R | [[Category: Offermann, L R]] | ||
[[Category: Bet v 1 like]] | [[Category: Bet v 1 like]] | ||
[[Category: Plant protein]] | [[Category: Plant protein]] | ||
[[Category: Small molecule carrier]] | [[Category: Small molecule carrier]] | ||
Revision as of 09:28, 5 January 2015
Crystal structure of Ara h 8 purified with heating
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