2hek: Difference between revisions

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[[Image:2hek.gif|left|200px]]<br /><applet load="2hek" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hek.gif|left|200px]]
caption="2hek, resolution 1.997&Aring;" />
 
'''Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.'''<br />
{{Structure
|PDB= 2hek |SIZE=350|CAPTION= <scene name='initialview01'>2hek</scene>, resolution 1.997&Aring;
|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+503'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+B+504'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+B+601'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+A+602'>AC6</scene>, <scene name='pdbsite=AC7:Br+Binding+Site+For+Residue+B+603'>AC7</scene>, <scene name='pdbsite=AC8:Cl+Binding+Site+For+Residue+A+604'>AC8</scene>, <scene name='pdbsite=AC9:Cl+Binding+Site+For+Residue+B+605'>AC9</scene>, <scene name='pdbsite=BC1:Cl+Binding+Site+For+Residue+A+606'>BC1</scene>, <scene name='pdbsite=BC2:Cl+Binding+Site+For+Residue+B+607'>BC2</scene>, <scene name='pdbsite=BC3:Cl+Binding+Site+For+Residue+B+608'>BC3</scene>, <scene name='pdbsite=BC4:Gdp+Binding+Site+For+Residue+A+401'>BC4</scene>, <scene name='pdbsite=BC5:Gdp+Binding+Site+For+Residue+A+402'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Residue+A+403'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Residue+A+404'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Residue+B+405'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Residue+A+406'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Residue+A+407'>CC1</scene>, <scene name='pdbsite=CC2:Gol+Binding+Site+For+Residue+A+408'>CC2</scene>, <scene name='pdbsite=CC3:Gol+Binding+Site+For+Residue+B+409'>CC3</scene> and <scene name='pdbsite=CC4:Gol+Binding+Site+For+Residue+A+410'>CC4</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY=
|GENE=
}}
 
'''Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
2HEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=BR:'>BR</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+503'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+B+504'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+B+601'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+A+602'>AC6</scene>, <scene name='pdbsite=AC7:Br+Binding+Site+For+Residue+B+603'>AC7</scene>, <scene name='pdbsite=AC8:Cl+Binding+Site+For+Residue+A+604'>AC8</scene>, <scene name='pdbsite=AC9:Cl+Binding+Site+For+Residue+B+605'>AC9</scene>, <scene name='pdbsite=BC1:Cl+Binding+Site+For+Residue+A+606'>BC1</scene>, <scene name='pdbsite=BC2:Cl+Binding+Site+For+Residue+B+607'>BC2</scene>, <scene name='pdbsite=BC3:Cl+Binding+Site+For+Residue+B+608'>BC3</scene>, <scene name='pdbsite=BC4:Gdp+Binding+Site+For+Residue+A+401'>BC4</scene>, <scene name='pdbsite=BC5:Gdp+Binding+Site+For+Residue+A+402'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Residue+A+403'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Residue+A+404'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Residue+B+405'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Residue+A+406'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Residue+A+407'>CC1</scene>, <scene name='pdbsite=CC2:Gol+Binding+Site+For+Residue+A+408'>CC2</scene>, <scene name='pdbsite=CC3:Gol+Binding+Site+For+Residue+B+409'>CC3</scene> and <scene name='pdbsite=CC4:Gol+Binding+Site+For+Residue+A+410'>CC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEK OCA].  
2HEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEK OCA].  


==Reference==
==Reference==
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17565173 17565173]
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17565173 17565173]
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 30: Line 39:
[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
[[Category: structural genomics]]
[[Category: structural genomic]]
[[Category: unknown function]]
[[Category: unknown function]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:41:00 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:16:02 2008''

Revision as of 15:16, 20 March 2008

File:2hek.gif


Drag the structure with the mouse to rotate
2hek, resolution 1.997Å
Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9, BC1, BC2, BC3, BC4, BC5, BC6, BC7, BC8, BC9, CC1, CC2, CC3 and CC4
Ligands: PO4, ZN, CL, BR, GDP and GOL
Coordinates: save as pdb, mmCIF, xml



Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.


Overview

Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed.

About this Structure

2HEK is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:17565173

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