2hi4: Difference between revisions

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[[Image:2hi4.gif|left|200px]]<br /><applet load="2hi4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hi4.gif|left|200px]]
caption="2hi4, resolution 1.950&Aring;" />
 
'''Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone'''<br />
{{Structure
|PDB= 2hi4 |SIZE=350|CAPTION= <scene name='initialview01'>2hi4</scene>, resolution 1.950&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=BHF:2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE'>BHF</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1]
|GENE= CYP1A2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HI4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=BHF:'>BHF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI4 OCA].  
2HI4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI4 OCA].  


==Reference==
==Reference==
Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2., Sansen S, Yano JK, Reynald RL, Schoch GA, Griffin KJ, Stout CD, Johnson EF, J Biol Chem. 2007 May 11;282(19):14348-55. Epub 2007 Feb 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17311915 17311915]
Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2., Sansen S, Yano JK, Reynald RL, Schoch GA, Griffin KJ, Stout CD, Johnson EF, J Biol Chem. 2007 May 11;282(19):14348-55. Epub 2007 Feb 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17311915 17311915]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: p450 1a2]]
[[Category: p450 1a2]]


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