2hkj: Difference between revisions

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[[Image:2hkj.gif|left|200px]]<br /><applet load="2hkj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hkj.gif|left|200px]]
caption="2hkj, resolution 2.00&Aring;" />
 
'''Topoisomerase VI-B bound to radicicol'''<br />
{{Structure
|PDB= 2hkj |SIZE=350|CAPTION= <scene name='initialview01'>2hkj</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene> and <scene name='pdbligand=RDC:RADICICOL'>RDC</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3]
|GENE= top6B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2286 Sulfolobus shibatae])
}}
 
'''Topoisomerase VI-B bound to radicicol'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HKJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_shibatae Sulfolobus shibatae] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=DMS:'>DMS</scene> and <scene name='pdbligand=RDC:'>RDC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKJ OCA].  
2HKJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_shibatae Sulfolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKJ OCA].  


==Reference==
==Reference==
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol., Corbett KD, Berger JM, Nucleic Acids Res. 2006;34(15):4269-77. Epub 2006 Aug 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16920739 16920739]
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol., Corbett KD, Berger JM, Nucleic Acids Res. 2006;34(15):4269-77. Epub 2006 Aug 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16920739 16920739]
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: topoisomerase]]
[[Category: topoisomerase]]


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