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[[Image:3ler.png|left|200px]]
==Crystal Structure of Dihydrodipicolinate Synthase from Campylobacter jejuni subsp. jejuni NCTC 11168==
 
<StructureSection load='3ler' size='340' side='right' caption='[[3ler]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
{{STRUCTURE_3ler|  PDB=3ler  |  SCENE=  }}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ler]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni Campylobacter jejuni subsp. jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LER FirstGlance]. <br>
===Crystal Structure of Dihydrodipicolinate Synthase from Campylobacter jejuni subsp. jejuni NCTC 11168===
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCL:NZ-(1-CARBOXYETHYL)-LYSINE'>MCL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32022 Campylobacter jejuni subsp. jejuni])</td></tr>
==About this Structure==
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>
[[3ler]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni Campylobacter jejuni subsp. jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LER OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ler FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ler OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ler RCSB], [http://www.ebi.ac.uk/pdbsum/3ler PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DAPA_CAMJE DAPA_CAMJE]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).[HAMAP-Rule:MF_00418]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/le/3ler_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dihydrodipicolinate Synthase|Dihydrodipicolinate Synthase]]
*[[Dihydrodipicolinate synthase|Dihydrodipicolinate synthase]]
__TOC__
</StructureSection>
[[Category: Campylobacter jejuni subsp. jejuni]]
[[Category: Campylobacter jejuni subsp. jejuni]]
[[Category: Dihydrodipicolinate synthase]]
[[Category: Dihydrodipicolinate synthase]]
[[Category: Anderson, W F.]]
[[Category: Anderson, W F]]
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
[[Category: Structural genomic]]
[[Category: Hasseman, J.]]
[[Category: Hasseman, J]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y.]]
[[Category: Kim, Y]]
[[Category: Zhou, M.]]
[[Category: Zhou, M]]
[[Category: Amino-acid biosynthesis]]
[[Category: Amino-acid biosynthesis]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Csgid]]
[[Category: Csgid]]
[[Category: Diaminopimelate biosynthesis]]
[[Category: Diaminopimelate biosynthesis]]
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[[Category: Lysine biosynthesis]]
[[Category: Lysine biosynthesis]]
[[Category: Schiff base]]
[[Category: Schiff base]]
[[Category: Structural genomic]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]