2hnd: Difference between revisions

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[[Image:2hnd.jpg|left|200px]]<br /><applet load="2hnd" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hnd.jpg|left|200px]]
caption="2hnd, resolution 2.50&Aring;" />
 
'''Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine'''<br />
{{Structure
|PDB= 2hnd |SIZE=350|CAPTION= <scene name='initialview01'>2hnd</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=NVP:11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE'>NVP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HND is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=NVP:'>NVP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HND OCA].  
2HND is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HND OCA].  


==Reference==
==Reference==
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138., Ren J, Nichols CE, Stamp A, Chamberlain PP, Ferris R, Weaver KL, Short SA, Stammers DK, FEBS J. 2006 Aug;273(16):3850-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16911530 16911530]
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138., Ren J, Nichols CE, Stamp A, Chamberlain PP, Ferris R, Weaver KL, Short SA, Stammers DK, FEBS J. 2006 Aug;273(16):3850-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16911530 16911530]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: NVP]]
[[Category: NVP]]
[[Category: PO4]]
[[Category: PO4]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: drug resistance mutations]]
[[Category: drug resistance mutation]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: nevirapine]]
[[Category: nevirapine]]
[[Category: non-nucleoside inhibitor]]
[[Category: non-nucleoside inhibitor]]


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