4r12: Difference between revisions
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''' | ==Crystal structure of the gamma-secretase component Nicastrin== | ||
<StructureSection load='4r12' size='340' side='right' caption='[[4r12]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R12 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r12 RCSB], [http://www.ebi.ac.uk/pdbsum/4r12 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
gamma-Secretase is an intramembrane protease responsible for the generation of amyloid-beta (Abeta) peptides. Aberrant accumulation of Abeta leads to the formation of amyloid plaques in the brain of patients with Alzheimer's disease. Nicastrin is the putative substrate-recruiting component of the gamma-secretase complex. No atomic-resolution structure had been identified on gamma-secretase or any of its four components, hindering mechanistic understanding of gamma-secretase function. Here we report the crystal structure of nicastrin from Dictyostelium purpureum at 1.95-A resolution. The extracellular domain of nicastrin contains a large lobe and a small lobe. The large lobe of nicastrin, thought to be responsible for substrate recognition, associates with the small lobe through a hydrophobic pivot at the center. The putative substrate-binding pocket is shielded from the small lobe by a lid, which blocks substrate entry. These structural features suggest a working model of nicastrin function. Analysis of nicastrin structure provides insights into the assembly and architecture of the gamma-secretase complex. | |||
Crystal structure of the gamma-secretase component nicastrin.,Xie T, Yan C, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13349-54. doi:, 10.1073/pnas.1414837111. Epub 2014 Sep 2. PMID:25197054<ref>PMID:25197054</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lu, P]] | |||
[[Category: Ma, D]] | |||
[[Category: Shi, Y]] | |||
[[Category: Sun, L]] | |||
[[Category: Xie, T]] | |||
[[Category: Yan, C]] | |||
[[Category: Yang, G]] | |||
[[Category: Zhao, Y]] | |||
[[Category: Zhou, R]] | |||
[[Category: Alpha/beta]] | |||
[[Category: Gamma-secretase complex]] | |||
[[Category: Nicastrin]] | |||
[[Category: Protein binding]] | |||
[[Category: Putative substrate-recruiting component]] | |||
Revision as of 14:58, 5 January 2015
Crystal structure of the gamma-secretase component Nicastrin
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