2hv9: Difference between revisions

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[[Image:2hv9.gif|left|200px]]<br /><applet load="2hv9" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hv9.gif|left|200px]]
caption="2hv9, resolution 2.60&Aring;" />
 
'''Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase in complex with sinefungin'''<br />
{{Structure
|PDB= 2hv9 |SIZE=350|CAPTION= <scene name='initialview01'>2hv9</scene>, resolution 2.60&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SFG:ADENOSYL-ORNITHINE'>SFG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56]
|GENE= Ecm1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])
}}
 
'''Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase in complex with sinefungin'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HV9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi] with <scene name='pdbligand=SFG:'>SFG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HV9 OCA].  
2HV9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HV9 OCA].  


==Reference==
==Reference==
Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity., Zheng S, Hausmann S, Liu Q, Ghosh A, Schwer B, Lima CD, Shuman S, J Biol Chem. 2006 Nov 24;281(47):35904-13. Epub 2006 Sep 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16971388 16971388]
Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity., Zheng S, Hausmann S, Liu Q, Ghosh A, Schwer B, Lima CD, Shuman S, J Biol Chem. 2006 Nov 24;281(47):35904-13. Epub 2006 Sep 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16971388 16971388]
[[Category: Encephalitozoon cuniculi]]
[[Category: Encephalitozoon cuniculi]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: mrna]]
[[Category: mrna]]


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