2hwh: Difference between revisions

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[[Image:2hwh.gif|left|200px]]<br /><applet load="2hwh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hwh.gif|left|200px]]
caption="2hwh, resolution 2.3&Aring;" />
 
'''HCV NS5B allosteric inhibitor complex'''<br />
{{Structure
|PDB= 2hwh |SIZE=350|CAPTION= <scene name='initialview01'>2hwh</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=RNA:4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE'>RNA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
|GENE=
}}
 
'''HCV NS5B allosteric inhibitor complex'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HWH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=RNA:'>RNA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HWH OCA].  
2HWH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HWH OCA].  


==Reference==
==Reference==
Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors., Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5888-91. Epub 2006 Aug 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16934455 16934455]
Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors., Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5888-91. Epub 2006 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16934455 16934455]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: viral rna-directed rna polymerase]]
[[Category: viral rna-directed rna polymerase]]


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