2ijn: Difference between revisions

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[[Image:2ijn.gif|left|200px]]<br /><applet load="2ijn" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ijn.gif|left|200px]]
caption="2ijn, resolution 2.20&Aring;" />
 
'''Isothiazoles as active-site inhibitors of HCV NS5B polymerase'''<br />
{{Structure
|PDB= 2ijn |SIZE=350|CAPTION= <scene name='initialview01'>2ijn</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=221:(2R,3R)-3-{[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO}-2-CYANO-3-THIOXOPROPANAMIDE'>221</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
|GENE=
}}
 
'''Isothiazoles as active-site inhibitors of HCV NS5B polymerase'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2IJN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_3b Hepatitis c virus subtype 3b] with <scene name='pdbligand=221:'>221</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IJN OCA].  
2IJN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_3b Hepatitis c virus subtype 3b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IJN OCA].  


==Reference==
==Reference==
Isothiazoles as active-site inhibitors of HCV NS5B polymerase., Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N, Bioorg Med Chem Lett. 2007 Jan 1;17(1):28-33. Epub 2006 Oct 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17049853 17049853]
Isothiazoles as active-site inhibitors of HCV NS5B polymerase., Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N, Bioorg Med Chem Lett. 2007 Jan 1;17(1):28-33. Epub 2006 Oct 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17049853 17049853]
[[Category: Hepatitis c virus subtype 3b]]
[[Category: Hepatitis c virus subtype 3b]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: hcv; ns5b; viral rna directed rna polymerase; rdrp; active site; covalent inhibitor]]
[[Category: hcv; ns5b; viral rna directed rna polymerase; rdrp; active site; covalent inhibitor]]


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