Tachyplesin: Difference between revisions

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[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Listeria monocytogenes] are Gram-negative and Gram-positive bacteria, respectively. They are the most common intestinal tract pathogenic bacteria in animals and humans.

Studying the effect of TP-I on E. coli and S. aureus will be valuable in guiding clinical practice.

The potential mechanism of E. coli membrane disruption by YP-I is the induction of macromolecule leakage into the cytoplasm and the release of potassium ions, leading to an increase in inner permeability, the formation of a toroidal pore, the neutralization of LPS, and the disruption of the permeability barrier of the outer membrane. TP-I killed E. coli mainly through cell membrane damage and intracellular esterase inactivation dependent on concentration.

In food production, requirements must be met for producing high quality food with minimal microbial contamination, and the determination of microbial viability based on different physiological and metabolic parameters is critical for acceptable sterilization. Therefore, the presence of injured, metabolically active bacteria is a very important aspect to consider in food production and for clinical applications. Sublethally injured cells might be repaired under suitable conditions. If TP-I is applied as a clinical treatment at a lower concentration than the MIC over a long period of time, drug resistance could develop.<ref name=Hong>Hong, Jun, et al. "Mechanism of tachyplesin I injury to bacterial membranes and intracellular enzymes, determined by laser confocal scanning microscopy and flow cytometry." Microbiological research (2014).‏</ref>

== Possible Function as anti-tumor peptide ==

Tachyplesin: Difference between revisions

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 [http://en.wikipedia.org/wiki/Escherichia_coli <i>Escherichia coli</i>] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus <i>Listeria monocytogenes</i>] are Gram-negative and Gram-positive bacteria, respectively. They are the most common intestinal tract pathogenic bacteria in animals and humans.
+Studying the effect of TP-I on <i>E. coli</i> and <i>S. aureus</i> will be valuable in guiding clinical practice.
+The potential mechanism of E. coli membrane disruption by YP-I is the induction of macromolecule leakage into the cytoplasm and the release of potassium ions, leading to an increase in inner permeability, the formation of a toroidal pore, the neutralization of LPS, and the disruption of the permeability barrier of the outer membrane. TP-I killed E. coli mainly through cell membrane damage and intracellular esterase inactivation dependent on concentration.
+In food production, requirements must be met for producing high quality food with minimal microbial contamination, and the determination of microbial viability based on different physiological and metabolic parameters is critical for acceptable sterilization. Therefore, the presence of injured, metabolically active bacteria is a very important aspect to consider in food production and for clinical applications. Sublethally injured cells might be repaired under suitable conditions. If TP-I is applied as a clinical treatment at a lower concentration than the MIC over a long period of time, drug resistance could develop.<ref name=Hong>Hong, Jun, et al. "Mechanism of tachyplesin I injury to bacterial membranes and intracellular enzymes, determined by laser confocal scanning microscopy and flow cytometry." Microbiological research (2014).‏</ref>
 == Possible Function as anti-tumor peptide ==