Sandbox Reserved 970: Difference between revisions
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== Introduction == | == Introduction == | ||
All living organisms depend on P-type ATPase to pump cation across the membrane. They play a fundamental role in their metabolism and physiology. Ca2+ ATPase is a P-type ATPase which transport calcium ions across the membrane against a concentration gradient forming a phosphorylated intermediate state (P-type). These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP broken, it transfers two calcium ions through the membrane, and two or three hydrogen ions back in the opposite direction. | |||
All living organisms depend on P-type ATPase to pump cation across the membrane. They play a fundamental role in their metabolism and physiology. Ca2+ ATPase is a P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP broken, it transfers two calcium ions through the membrane, and two or three hydrogen ions back in the opposite direction. | |||
<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref> | <ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref> | ||
