2mjc: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Zn-binding domain of eukaryotic translation initiation factor 3, subunit G==

~~The entry~~ 2mjc is ~~ON HOLD until Jan 07 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2mjc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MJC FirstGlance]. <br>

~~Authors~~: Al-~~Abdul~~-~~Wahid~~, M.~~, Menade, M~~., ~~Xie, J~~.~~, Kozlov, G~~.~~, Gehring, K~~.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjc RCSB], [http://www.ebi.ac.uk/pdbsum/2mjc PDBsum]</span></td></tr>

~~Description~~: ~~Zn-binding domain~~ of eukaryotic translation initiation factor 3, subunit G

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/EIF3G_HUMAN EIF3G_HUMAN]] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.

__TOC__

</StructureSection>

[[Category: Al-Abdul-Wahid, M]]

[[Category: Gehring, K]]

[[Category: Kozlov, G]]

[[Category: ~~Gehring~~, K]]

[[Category: Menade, M]]

[[Category: Xie, J]]

[[Category: ~~Menade, M~~]]

[[Category: Metal binding protein]]

[[Category: Al-~~Abdul-Wahid, M~~]]

[[Category: Zinc-binding domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Zn-binding domain of eukaryotic translation initiation factor 3, subunit G==
+<StructureSection load='2mjc' size='340' side='right' caption='[[2mjc]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
-The entry 2mjc is ON HOLD  until Jan 07 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2mjc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MJC FirstGlance]. <br>
-Authors: Al-Abdul-Wahid, M., Menade, M., Xie, J., Kozlov, G., Gehring, K.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjc RCSB], [http://www.ebi.ac.uk/pdbsum/2mjc PDBsum]</span></td></tr>
-Description: Zn-binding domain of eukaryotic translation initiation factor 3, subunit G
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/EIF3G_HUMAN EIF3G_HUMAN]] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.
+__TOC__
+</StructureSection>
+[[Category: Al-Abdul-Wahid, M]]
+[[Category: Gehring, K]]
 [[Category: Kozlov, G]]
-[[Category: Gehring, K]]
+[[Category: Menade, M]]
 [[Category: Xie, J]]
-[[Category: Menade, M]]
+[[Category: Metal binding protein]]
-[[Category: Al-Abdul-Wahid, M]]
+[[Category: Zinc-binding domain]]