4qt6: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of the SPRY domain of human HERC1==

~~The entry~~ 4qt6 is ~~ON HOLD until Jan 07 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QT6 FirstGlance].

~~Authors~~: ~~Dong, A~~.~~, Hu, J~~., ~~Guan, X~~.~~, Wernimont, A~~.~~, Li, Y~~., ~~Bountra, C~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.M.~~, Tong, Y~~.~~, Structural Genomics Consortium (SGC)~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

~~Description~~: ~~Crystal structure~~ of the ~~SPRY domain of human HERC1 (CASP Target)~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qt6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qt6 PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Arrowsmith~~, C.H]]

== Function ==

[[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Dong, A]]

[[Category: Edwards, A M]]

[[Category: Guan, X]]

[[Category: Hu, J]]

[[Category: Li, Y]]

[[Category: ~~Hu, J~~]]

[[Category: Structural genomic]]

[[Category: ~~Guan~~, X]]

[[Category: Tong, Y]]

[[Category: Wernimont, A]]

[[Category: ~~Tong, Y~~]]

[[Category: B30 2]]

[[Category: ~~Edwards, A.M~~]]

[[Category: E3 ubiquitin ligase]]

[[Category: ~~Structural Genomics Consortium (~~Sgc)]]

[[Category: Herc1]]

[[Category: ~~Bountra, C~~]]

[[Category: Sgc]]

[[Category: Spry]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of the SPRY domain of human HERC1==
+<StructureSection load='4qt6' size='340' side='right' caption='[[4qt6]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
-The entry 4qt6 is ON HOLD  until Jan 07 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QT6 FirstGlance]. <br>
-Authors: Dong, A., Hu, J., Guan, X., Wernimont, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-Description: Crystal structure of the SPRY domain of human HERC1 (CASP Target)
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qt6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qt6 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Arrowsmith, C.H]]
+== Function ==
+[[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
 [[Category: Dong, A]]
+[[Category: Edwards, A M]]
+[[Category: Guan, X]]
+[[Category: Hu, J]]
 [[Category: Li, Y]]
-[[Category: Hu, J]]
+[[Category: Structural genomic]]
-[[Category: Guan, X]]
+[[Category: Tong, Y]]
 [[Category: Wernimont, A]]
-[[Category: Tong, Y]]
+[[Category: B30 2]]
-[[Category: Edwards, A.M]]
+[[Category: E3 ubiquitin ligase]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Herc1]]
-[[Category: Bountra, C]]
+[[Category: Sgc]]
+[[Category: Spry]]
+[[Category: Transport protein]]