Sandbox Reserved 954: Difference between revisions
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==Introduction== | ==Introduction== | ||
Squamous cell carcinoma antigen is a tumor associated protein of squamous cell carcinoma of various organs. SCCA was originally purified from SCC of the uterine cervix <ref>Martz, E. Book review of ''Introduction to protein science—architecture, function, and genomics: Lesk, Arthur M. Biochem. Mol. Biol. Educ.'' 33:144-5 (2006). [http://link.springer.com/chapter/10.1007/978-1-4612-0401-5_21#page-1 DOI :10.1007/978-1-4612-0401-5_21#page-1]</ref>. SCCA is a tumor marker to detect malignant tumor and to understand biological behaviors of squamous cells. SCCA is classified as a serine protease inhibitor called [http://en.wikipedia.org/wiki/Serpin | Squamous cell carcinoma antigen is a tumor associated protein of squamous cell carcinoma of various organs. SCCA was originally purified from SCC of the uterine cervix <ref>Martz, E. Book review of ''Introduction to protein science—architecture, function, and genomics: Lesk, Arthur M. Biochem. Mol. Biol. Educ.'' 33:144-5 (2006). [http://link.springer.com/chapter/10.1007/978-1-4612-0401-5_21#page-1 DOI :10.1007/978-1-4612-0401-5_21#page-1]</ref>. SCCA is a [http://en.wikipedia.org/wiki/Tumor_marker tumor marker] to detect malignant tumor and to understand biological behaviors of squamous cells. SCCA is classified as a serine protease inhibitor called [http://en.wikipedia.org/wiki/Serpin serpin] B3. It also inhibits [http://en.wikipedia.org/wiki/Chymotrypsin chymotripsin], [http://en.wikipedia.org/wiki/Cathepsin cathepsin] L, K and S and papain like cysteine proteases. In the case of tumor development SCCA 1 inhibits NK cells(natural killer), TNFalfa and apoptosis of tumor cells induced by treatment. It can also play a role in tumor growth. The chromosomal location is the locus 18q21.3.<ref>PMID:9817978</ref> | ||
==Structure== | ==Structure== | ||
