Sandbox Reserved 970: Difference between revisions

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== Introduction ==
== Introduction ==


All living organisms depend on P-type ATPase to pump cations across membranes. They play a fundamental role in their metabolism and physiology. Ca2+ ATPase is a P-type ATPase which transport calcium ions across the membrane against a concentration gradient forming a phosphorylated intermediate state (P-type). These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP hydrolysed, it transfers two calcium ions through the membrane, and two or three hydrogen ions in the opposite direction.
P-type ATPase pump cations across membranes. These transporters are characterized by a phosphorylated intermediate state. They play a fundamental role in organisms metabolism and physiology. Ca2+ ATPase is a P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP hydrolysed, it transfers two calcium ions through the membrane, and two or three hydrogen ions in the opposite direction.
<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref>
<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref>


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