Sandbox Reserved 970: Difference between revisions
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== Introduction == | == Introduction == | ||
P-type ATPase pump cations across membranes. | P-type ATPase pump cations across membranes. They are dictinc from other ATPases by an autophosphorylation step. They play a fundamental role in organisms metabolism and physiology. Ca2+ ATPase is one type of P-type ATPase which transport calcium ions across the membrane against a concentration gradient. These pumps clear cytoplasm of the second messenger, the calcium. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP hydrolysed, it transfers two calcium ions through the membrane, and two or three hydrogen ions in the opposite direction. | ||
<ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref> | <ref name="second"> David Goodsell, 2004 - Calcium pump molecul of the month - PDB, doi: 10.2210/rcsb_pdb/mom_2004_3</ref> | ||
