Sandbox Reserved 954: Difference between revisions
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NH2-terminal kinase | NH2-terminal kinase | ||
http://jcb.rupress.org/content/172/7/983.full.pdf+html DOI : 172/7/983.full.pdf+html </ref> | http://jcb.rupress.org/content/172/7/983.full.pdf+html DOI : 172/7/983.full.pdf+html </ref> | ||
Indeed the reactive center loop (<scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene>) of SCCA1 is very flexible and located away from the center of SCCA1. The inhibitory effect of SCCA1 on the kinase activity of JNK1 is lost when the RCL was truncated. Furthermore, a mutant protein created by replacing one amino acid in <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased. | Indeed the reactive center loop (<scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene>) of SCCA1 is very flexible and located away from the center of SCCA1. The inhibitory effect of SCCA1 on the kinase activity of JNK1 is lost when the <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> was truncated. Furthermore, a mutant protein created by replacing one amino acid in <scene name='60/604473/The_rcl_loop_scene/3'>RCL</scene> maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased. | ||
<ref> PMID : 19166818<ref> | <ref> PMID : 19166818<ref> | ||
