2iya: Difference between revisions

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[[Image:2iya.gif|left|200px]]<br /><applet load="2iya" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2iya.gif|left|200px]]
caption="2iya, resolution 1.70&Aring;" />
 
'''THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING'''<br />
{{Structure
|PDB= 2iya |SIZE=350|CAPTION= <scene name='initialview01'>2iya</scene>, resolution 1.70&Aring;
|SITE= <scene name='pdbsite=AC1:Udp+Binding+Site+For+Residue+A+1424'>AC1</scene>, <scene name='pdbsite=AC2:Zio+Binding+Site+For+Residue+A+1425'>AC2</scene>, <scene name='pdbsite=AC3:Udp+Binding+Site+For+Residue+B+1424'>AC3</scene> and <scene name='pdbsite=AC4:Zio+Binding+Site+For+Residue+B+1425'>AC4</scene>
|LIGAND= <scene name='pdbligand=UDP:URIDINE-5'-DIPHOSPHATE'>UDP</scene> and <scene name='pdbligand=ZIO:(3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE'>ZIO</scene>
|ACTIVITY=
|GENE=
}}
 
'''THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2IYA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus] with <scene name='pdbligand=UDP:'>UDP</scene> and <scene name='pdbligand=ZIO:'>ZIO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Udp+Binding+Site+For+Residue+A+1424'>AC1</scene>, <scene name='pdbsite=AC2:Zio+Binding+Site+For+Residue+A+1425'>AC2</scene>, <scene name='pdbsite=AC3:Udp+Binding+Site+For+Residue+B+1424'>AC3</scene> and <scene name='pdbsite=AC4:Zio+Binding+Site+For+Residue+B+1425'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYA OCA].  
2IYA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYA OCA].  


==Reference==
==Reference==
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity., Bolam DN, Roberts S, Proctor MR, Turkenburg JP, Dodson EJ, Martinez-Fleites C, Yang M, Davis BG, Davies GJ, Gilbert HJ, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5336-41. Epub 2007 Mar 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17376874 17376874]
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity., Bolam DN, Roberts S, Proctor MR, Turkenburg JP, Dodson EJ, Martinez-Fleites C, Yang M, Davis BG, Davies GJ, Gilbert HJ, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5336-41. Epub 2007 Mar 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17376874 17376874]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces antibioticus]]
[[Category: Streptomyces antibioticus]]
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[[Category: transferase]]
[[Category: transferase]]


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