2iz1: Difference between revisions

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[[Image:2iz1.gif|left|200px]]<br /><applet load="2iz1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2iz1.gif|left|200px]]
caption="2iz1, resolution 2.30&Aring;" />
 
'''6PDH COMPLEXED WITH PEX INHIBITOR SYNCHROTRON DATA'''<br />
{{Structure
|PDB= 2iz1 |SIZE=350|CAPTION= <scene name='initialview01'>2iz1</scene>, resolution 2.30&Aring;
|SITE= <scene name='pdbsite=AC1:Peg+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ATR:2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE'>ATR</scene>, <scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(decarboxylating) Phosphogluconate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44]
|GENE=
}}
 
'''6PDH COMPLEXED WITH PEX INHIBITOR SYNCHROTRON DATA'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2IZ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=ATR:'>ATR</scene>, <scene name='pdbligand=RES:'>RES</scene>, <scene name='pdbligand=P33:'>P33</scene> and <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(decarboxylating) Phosphogluconate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] Known structural/functional Site: <scene name='pdbsite=AC1:Peg+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZ1 OCA].  
2IZ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZ1 OCA].  


==Reference==
==Reference==
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates., Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN, FEBS J. 2007 Jan;274(1):275-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17222187 17222187]
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates., Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN, FEBS J. 2007 Jan;274(1):275-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17222187 17222187]
[[Category: Lactococcus lactis]]
[[Category: Lactococcus lactis]]
[[Category: Phosphogluconate dehydrogenase (decarboxylating)]]
[[Category: Phosphogluconate dehydrogenase (decarboxylating)]]
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[[Category: pentose shunt]]
[[Category: pentose shunt]]


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