2j6k: Difference between revisions
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[[Image:2j6k.jpg|left|200px]] | [[Image:2j6k.jpg|left|200px]] | ||
'''N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)''' | {{Structure | ||
|PDB= 2j6k |SIZE=350|CAPTION= <scene name='initialview01'>2j6k</scene>, resolution 2.775Å | |||
|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene> | |||
|LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2J6K is a [ | 2J6K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6K OCA]. | ||
==Reference== | ==Reference== | ||
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:[http:// | Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17020880 17020880] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cd2 associated protein]] | [[Category: cd2 associated protein]] | ||
[[Category: coiled coil]] | [[Category: coiled coil]] | ||
[[Category: cytoskeletal | [[Category: cytoskeletal rearrangement]] | ||
[[Category: egfr downregulation]] | [[Category: egfr downregulation]] | ||
[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
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[[Category: surface active protein]] | [[Category: surface active protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:37:54 2008'' | ||
Revision as of 15:37, 20 March 2008
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| 2j6k, resolution 2.775Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | NA | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)
Overview
The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic adaptor proteins has the ability to engage multiple effectors and couple cargo trafficking with the cytoskeleton. CIN85 and CMS (Cas ligand with multiple Src homology 3 (SH3) domains) facilitate the formation of large multiprotein complexes required for an efficient internalization of cell surface receptors. It has recently been shown that c-Cbl/Cbl-b could mediate the formation of a ternary complex between one c-Cbl/Cbl-b molecule and two SH3 domains of CIN85, important for the ability of Cbl to promote epidermal growth factor receptor down-regulation. To further investigate whether multimerization is conserved within the family of adaptor proteins, we have solved the crystal structures of the CMS N-terminal SH3 domain-forming complexes with Cbl-b- and CD2-derived peptides. Together with biochemical evidence, the structures support the notion that, despite clear differences in the interaction surface, both Cbl-b and CD2 can mediate multimerization of N-terminal CMS SH3 domains. Detailed analyses on the interacting surfaces also provide the basis for a differential Cbl-b molecular recognition of CMS and CIN85.
About this Structure
2J6K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880
Page seeded by OCA on Thu Mar 20 17:37:54 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Bravo, J.
- Cardenes, N.
- Deribe, Y L.
- Dikic, I.
- Moncalian, G.
- Spinola-Amilibia, M.
- NA
- Adaptor protein
- Cd2 associated protein
- Coiled coil
- Cytoskeletal rearrangement
- Egfr downregulation
- Phosphorylation
- Protein binding
- Sh3
- Sh3 domain
- Sh3-binding
- Signaling protein
- Surface active protein
