Sandbox Reserved 973: Difference between revisions

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== Diseases ==

As we mentionned it above, several mutations of the complex can alter the circadian rhythm. These mutation can affect the structure of the heterodimer and its ability to bind DNA, endanger its stability or modify the interactions with co-regulator clock elements. However, many of them are responseable for numerous pathologies as they have an impact on the whole clock system, involved in different functions, depending on the tissue type. In mamals, an increasing number of disorders are thought to be linked with the clock proteins dysfunction. For the single CLOCK:BMAL1 complex, mutations are related to various troubles such as infertility, progressive arthropathy, abnormal gluconeogenesis, abnormal lipogenesis or altered sleep pattern. The complex plays a major role in cellular metabolic pathway so it is linked to hepatic steatosis, hyperleptinemia, hyperglycemia and hypoinsulinemia. BMAL1 is necessary for embryonic fibroblast cells to differenciate into adipocytes. Moreover, other disrupted genes such as mutated Per or Cry must be taken into account because they also disturb the proper working of the complex, laeding to other disorders.

As we mentionned it above, several mutations of the complex can alter the circadian rhythm. These mutation can affect the structure of the heterodimer and its ability to bind DNA, endanger its stability or modify the interactions with co-regulator clock elements. However, many of them are responseable for numerous pathologies as they have an impact on the whole clock system, involved in different functions, depending on the tissue type. In mamals, an increasing number of disorders are thought to be linked with the clock proteins dysfunction. For the single CLOCK:BMAL1 complex, mutations are related to various troubles such as infertility, progressive arthropathy, abnormal gluconeogenesis, abnormal lipogenesis or altered sleep pattern. The complex plays a major role in cellular metabolic pathway so it is linked to hepatic steatosis, hyperleptinemia, hyperglycemia and hypoinsulinemia. BMAL1 is also necessary for embryonic fibroblast cells to differenciate into adipocytes. Another unexpected aspect of the heterodimer functions is that it can influence the efficacy of some drugs. For example, muatnts that don't own this complex show a good response to chemotherapy all day long whereas it varies for the wild mice. Moreover, other disrupted genes such as mutated Per or Cry must be taken into account because they also disturb the proper working of the complex, laeding to other disorders.

== Structural highlights ==

Sandbox Reserved 973: Difference between revisions

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 == Diseases ==
-As we mentionned it above, several mutations of the complex can alter the circadian rhythm. These mutation can affect the structure of the heterodimer and its ability to bind DNA, endanger its stability or modify the interactions with co-regulator clock elements. However, many of them are responseable for numerous pathologies as they have an impact on the whole clock system, involved in different functions, depending on the tissue type. In mamals, an increasing number of disorders are thought to be linked with the clock proteins dysfunction. For the single CLOCK:BMAL1 complex, mutations are related to various troubles such as infertility, progressive arthropathy, abnormal gluconeogenesis, abnormal lipogenesis or altered sleep pattern. The complex plays a major role in cellular metabolic pathway so it is linked to hepatic steatosis, hyperleptinemia, hyperglycemia and hypoinsulinemia. BMAL1 is necessary for embryonic fibroblast cells to differenciate into adipocytes. Moreover, other disrupted genes such as mutated Per or Cry must be taken into account because they also disturb the proper working of the complex, laeding to other disorders.
+As we mentionned it above, several mutations of the complex can alter the circadian rhythm. These mutation can affect the structure of the heterodimer and its ability to bind DNA, endanger its stability or modify the interactions with co-regulator clock elements. However, many of them are responseable for numerous pathologies as they have an impact on the whole clock system, involved in different functions, depending on the tissue type. In mamals, an increasing number of disorders are thought to be linked with the clock proteins dysfunction. For the single CLOCK:BMAL1 complex, mutations are related to various troubles such as infertility, progressive arthropathy, abnormal gluconeogenesis, abnormal lipogenesis or altered sleep pattern. The complex plays a major role in cellular metabolic pathway so it is linked to hepatic steatosis, hyperleptinemia, hyperglycemia and hypoinsulinemia. BMAL1 is also necessary for embryonic fibroblast cells to differenciate into adipocytes. Another unexpected aspect of the heterodimer functions is that it can influence the efficacy of some drugs. For example, muatnts that don't own this complex show a good response to chemotherapy all day long whereas it varies for the wild mice. Moreover, other disrupted genes such as mutated Per or Cry must be taken into account because they also disturb the proper working of the complex, laeding to other disorders.
 == Structural highlights ==