Sandbox Reserved 970: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
== Introduction == | == Introduction == | ||
All living organisms depend on P-type ATPase to pump | All living organisms depend on P-type ATPase to pump cations across membranes. P-type ATPases are distinct from other ATPases because there is an autophosphorylation step in their catalytic cycle. They play a fundamental role in organisms metabolism and physiology. Ca2+ ATPase is one type of P-type ATPases which transports calcium ions across membranes against a concentration gradient. These pumps clear the cytoplasm of the calcium, which is a second messenger. It's very important to keep a low concentration of calcium in the cell for a good cell signaling. The hydrolysis of ATP is necessary for the pump's functioning. For each ATP hydrolyzed, it transfers two calcium ions through the membrane, and two or three hydrogen ions in the opposite direction. | ||