Sandbox Reserved 967: Difference between revisions
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==Structure of the Mouse RNase H2 Complex== | ==Structure of the Mouse RNase H2 Complex== | ||
<StructureSection load='3kio' size='400' side='right' caption='mouse RNase H2 complex, (PDB code [[3kio]])> | <StructureSection load='3kio' size='400' side='right' caption='mouse RNase H2 complex, (PDB code [[3kio]])> | ||
'''The RNase H2 ribonuclease complex''' is a heterotrimeric endoribonuclease responsible for the major ribonuclease H activity in mammalian cells. In mouse, the complex is encoded by 3 genes located on chromosomes 8 (''Rnaseh2a''), 14 (''Rnaseh2b'') and 19 (''Rnaseh2c''). This enzyme specifically cleaves the 3’O-Phosphate bond of RNA in a DNA/RNA hybrids to produce 5’ phosphate and 3’hydroxyl ends. | '''The RNase H2 ribonuclease complex''' is a heterotrimeric endoribonuclease responsible for the major ribonuclease H activity in mammalian cells. In mouse, the complex is encoded by 3 genes located on chromosomes 8 (''Rnaseh2a''), 14 (''Rnaseh2b'') and 19 (''Rnaseh2c'')<ref> http://genome-euro.ucsc.edu/cgi-bin/hgTracks?clade=mammal&org=Mouse&db=mm10&position=RnaseH2&hgt.positionInput=RnaseH2&hgt.suggestTrack=knownGene&Submit=submit&hgsid=201143152_yP1Xd4bMnHS7DV0d3VcqpDSxzzuQ&pix=1563</ref>. This enzyme specifically cleaves the 3’O-Phosphate bond of RNA in a DNA/RNA hybrids to produce 5’ phosphate and 3’hydroxyl ends. | ||
