Sandbox Reserved 954: Difference between revisions
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This move induce a protease distortion into a conformation, in which the acyl enzyme intermediate is hydrolysed extremely slowly. The active site of the enzyme would be expected to break.The protease thus remains covalently attached to the target protease and is thereby inhibited. | This move induce a protease distortion into a conformation, in which the acyl enzyme intermediate is hydrolysed extremely slowly. The active site of the enzyme would be expected to break.The protease thus remains covalently attached to the target protease and is thereby inhibited. | ||
[[Image:Antitrypsin-rasmol.jpg|center|thumbnail|750px|'''Protease inhibition by SERPIN B3''']] | [[Image:Antitrypsin-rasmol.jpg|center|thumbnail|750px|'''Protease inhibition by SERPIN B3<ref>http://www.rcsb.org/pdb/101/motm.do?momID=53</ref>''']] | ||
Consequently, the serpin has to be cleaved to inhibit the target protases. Thus, SCCA1 is irreversible protease inhibitor. | Consequently, the serpin has to be cleaved to inhibit the target protases. Thus, SCCA1 is irreversible protease inhibitor. | ||
